Gal-4 has a dual function in regulating the immune system: it can increase IL-6 secretion by CD4 + T cells, exacerbating inflammatory responses, while also binding to N-glycosylated residues on the CD3ε/δ surface receptors of T cells, promoting tumor immune tolerance and inducing apoptosis in T cells. The gene discussed is LGALS4; the disease is neoplasm.