On multivariate analysis (excluding NLR, mGPS and LDH) metastatic disease (p = 0.004), ECOG-PS (p = 0.019), LCAS (p < 0.01, Fig. 1) and LIPI (p < 0.01), but not GRIm, remained independently associated with 1-year survival. The gene discussed is LIPI; the disease is metastatic neoplasm.