T The systemic inflammatory response observed in patients with cancer cachexia, characterized by alterations in peripheral blood cells and inflammatory proteins such as the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte–C-reactive protein (CRP) ratio (LCR), and inflammatory burden index (IBI), has been independently associated with prognosis [7–9]. This evidence concerns the gene CRP and cancer.