CDKAL1 and Large for gestational age: Our study aimed to test the association of maternal CDKAL1 gene variants with the risk of adverse pregnancy outcome (APO), including any of preterm birth, low birth weight, or macrosomia, and whether it was mediated by GDM, based on a previous nested case–control study in a prospective cohort of pregnant women with GDM in Tianjin, China [14].