ERBB2 and breast cancer: Furthermore, lower miRNAs-449 expression levels were found in BC patients’ tissue when compared with healthy tissue (p = 0.0006) (Fig. 1B) and it was associated with worse OS in HER2 + BC patients (miRNA-449a: p = 0.1500; miRNA-449b-5p: p = 0.0750; miRNA-449c-5p: p = 0.0009) (Fig. 1C) through in silico analyses.