Autosomal recessive congenital ichthyosis, a condition characterized by excessive water loss from the skin epithelium leading to severe dryness, has been linked to mutations in genes encoding 12R-LOX and epidermal lipoxygenase 3 (eLOX-3) [32, 33]. The gene discussed is ALOXE3; the disease is autosomal recessive congenital ichthyosis.