In the treatment of chronic non-allergic rhinitis/rhinosinusitis, a significant improvement in symptoms such as headache (Passali et al. 2008a) and nasal obstruction (Passariello et al. 2012) is reported, as well as in parameters such as nasal resistance (Ottaviano et al. 2011, 2012; Staffieri et al. 2007), number of sleep arousal (Passali et al. 2008b), reduction of TNF-alpha, calprotectin and hBD-2 concentration (Passariello et al. 2012) and reduction of serum IgE concentration (Salami et al. 2010). This evidence concerns the gene IGHE and allergic rhinitis.