We identified multiple genes that are robustly differentially expressed in AF, including genes with known roles in CMs (HCN4, RCAN1, CALM3 and RGS6) as well as those that have been less studied in this cell type (ANGPTL2, REC114, RNF216, C4orf54, LINC01479 and IFNG-AS1). Here, RNF216 is linked to atrial fibrillation.