We identified multiple genes that are robustly differentially expressed in AF, including genes with known roles in CMs (HCN4, RCAN1, CALM3 and RGS6) as well as those that have been less studied in this cell type (ANGPTL2, REC114, RNF216, C4orf54, LINC01479 and IFNG-AS1). This evidence concerns the gene REC114 and atrial fibrillation.