After adjustments with confounders including age, gender, BMI, drinking status, smoking status, and the timing of blood collection, Cox regression analysis confirmed the above observation that lower NAT2 demethylation index was associated with a higher rate of ATDILI occurrence in tuberculosis patients (hazard ratio, HR 2.617; 95% CI 1.107, 6.182; P = 0.028). The gene discussed is NAT2; the disease is tuberculosis.