However, REGENIE found one significant genome-wide SNV, rs28451064 (Supplementary Table S8) in the known CAD locus 21q22.11 (KCNE2)18 and VariantSpark also identifies this SNV as the top association (Supplementary Table S9), demonstrating that these ML-based approaches were more sensitive than sLR in this analysis. This evidence concerns the gene KCNE2 and coronary artery disorder.