Similarly, in the retina of diabetic mice, low-dose IL-2 increased Tregs (Fig. 6) and reduced CD8+ T cells compared with untreated diabetic mice (untreated diabetes: 4.65 ± 0.58 vs diabetes + low-dose IL-2: 3.00 ± 0.81 cells per field, p<0.01) (Fig. 7d–g). This evidence concerns the gene CD8A and diabetes mellitus.