TNF and chronic obstructive pulmonary disease: Furthermore, Ogn was significantly downregulated in murine fibroblasts from resorted organoids treated for 72 h with an exacerbation cocktail (EC) containing COPD-related cytokines (300 pg/mL IL-1β, 300 pg/mL IL-6, 20 ng/mL keratinocyte chemoattractant, and 200 pg/mL TNFα) (Fig. 3f)24.