PRKN and Parkinson disease: We screened a large cohort of PD cases and controls with short-read whole-genome sequencing (WGS) data, including 16,351 individuals from GP2 release 8 (DOI 10.5281/zenodo.13755496) and AMP-PD release 4 (for details see Methods and Supplementary Table 1) to identify recurrent rare coding variants of unknown significance co-segregating with PD in known PD genes (LRRK2, SNCA, VPS35, PINK1, PRKN, PARK7, and GBA1).