ATG5 and breast cancer: Among them, Atg5 is an important gene in mammalian autophagy, serving as a key promoter of early autophagy [40].To determine whether ATP6AP1 promotes luminal breast cancer cell proliferation and TAM resistance through autophagy activation, we blocked autophagy by knocking down ATG5 using specific shRNA (Figs. 6A, B, S5A, B).