Among them, Atg5 is an important gene in mammalian autophagy, serving as a key promoter of early autophagy [40].To determine whether ATP6AP1 promotes luminal breast cancer cell proliferation and TAM resistance through autophagy activation, we blocked autophagy by knocking down ATG5 using specific shRNA (Figs. 6A, B, S5A, B). Here, ATP6AP1 is linked to breast carcinoma.