The results indicated that the concentration of PLOD3 in the medium of PLOD3-overexpressing DLD-1 cells was relatively higher than that in the medium of vector-transfected DLD-1 cells (Fig. 8A), suggesting that PLOD3 can be secreted by CRC cells.Then, conditional medium (CM) from PLOD3-overexpressing and vector-transfected DLD-1 cells was collected. This evidence concerns the gene PLOD3 and colorectal carcinoma.