IL6 and periodontitis: In addition, the knockdown of EZH2 has been demonstrated to facilitate PDLSCs osteogenic differentiation by inhibiting the TLR4/MyD88/NF-κB signaling pathway.118 In the initial stages of periodontitis, KDM6B is recruited to the promoters of IL-6 and IL-12β, leading to H3K27me3 removal and the activation of target genes that regulate the inflammatory response.134 Insulin-like growth factors (IGFs) and their binding proteins (IGFBP5) have been linked to processes such as cell growth, bone repair, and remodeling.