ChIP analysis confirmed that KDM5A binds to the miR-495-3p promoter and inhibits the expression of miR-495-3p by demethylating H3K4me3, thereby enhancing HOXC8 transcription and inhibiting the osteogenic differentiation, proliferation, and migration of hPDLSCs in patients with periodontitis.85 miR-590-3p targets LSD1 transcription, upregulates H3K4me2 methylation, and promotes OSX transcription, which in turn facilitates the osteogenic differentiation of hPDLSCs in periodontitis.84 This evidence concerns the gene KDM5A and periodontitis.