Additionally, it facilitates transcriptional elongation and gene expression through its effect on RNA polymerase II (Pol II).128 KDM6B has been the subject of extensive studies in the context of immune diseases, cancer, and tumor development as well as in pluripotent stem cells and fate determination.129,130 The osteogenic differentiation of BM-MSCs is a process in which KDM6B is responsible for the removal of methyl groups from histones situated within the promoters of BMP2, BMP4, and HOXC6-1. This evidence concerns the gene KDM6B and immune system disorder.