LSD1 occupies the binding site for H3K4me2/3, and its activity is essential for the normal formation of bone tissue.73 The administration of LSD1 inhibitors have been demonstrated to prevent osteoporosis after ovarietomy (OVX) in mice by increasing the number of osteoblasts.74 KDM1A/LSD1 has been shown to exhibit dynamic bidirectional effects during osteogenic/odontogenic differentiation of DMSCs. The gene discussed is KDM1A; the disease is osteoporosis.