However, only a few studies have directly demonstrated alterations in KDM6A gene expression in patients with periodontitis.52 LncRNA HOTAIRM1 has been shown to upregulate KDM6A/B expression and suppress EZH2 in a HIF-1α-dependent manner, thereby reducing the distribution of H3K27me3 of ALP, M-CSF, Wnt-3a, Wnt-5a, Wnt-7a, β-catenin and others. The gene discussed is EZH2; the disease is periodontitis.