YTHDC1 and urinary bladder cancer: YTHDC1 is known to act as a tumor suppressor in bladder cancer and to affect expression of downstream genes by modification of m6A. However, there are no reports on the involvement of XIAP in modification of m6A. To confirm whether XIAP promotes metastasis of bladder cancer cells via an effect on YTHDC1, we transfected YTHDC1 knockdown and control plasmids into UMUC3 (KO-XIAP), T24T (KO-XIAP), and wild-type cells to construct stable cells (Figs. 3A, D and S2A, B).