Transwell assays confirmed that knockdown of YTHDC1 in UMUC3 (KO-XIAP), T24T (KO-XIAP) and wild-type cells markedly reversed invasion of bladder cancer cells in comparison with control cells in vitro (Figs. 3B, C, E, F and S2C–F). This evidence concerns the gene XIAP and urinary bladder cancer.