It also remains unclear if and how results from studies employing overexpressed receptors in HEK293 cells can be translated to native settings to draw any conclusions on signaling and the role of GPR61 in obesity, particularly given that the levels of physiological expression of GPR61 RNA and protein in seemingly the most relevant organ for metabolism and food intake regulation, brain are only moderate (https://www.proteinatlas.org/ENSG00000156097-GPR61). Here, GPR61 is linked to obesity disorder.