MDM4 and cancer: Consistent with previous studies, the expression of cancer-related genes was inhibited in alpha1-oleate–treated cells and a broad apoptotic response was activated (P-value 1.2 × 10−47, 318 regulated genes), including CASP9, BCL2A1, BCL3, BCL6, MCL1, MDM1, MDM4, and NF-κB family genes (Fig 4G).