GLP1R and obesity due to melanocortin 4 receptor deficiency: Clinical trials are needed to demonstrate the clinical potential of GLP-1 RA for improving cardiovascular outcomes in patients with ACHD.PerspectivesCOMPETENCY IN PRACTICE-BASED LEARNING: GLP-1 RAs are effective for weight loss in patients with adult congenital heart disease, especially those with class II and III obesity.