CD4 and infection: To test this, we transferred Prr13-deficient (CD4-Cre Prr13(f/f)) or Prr13-sufficient (Prr13(f/f)) PbTII cells into congenic recipient mice, and assessed splenic and hepatic responses at 7- and 28-days post-infection with anti-malarial drug treatment from day 7 p.i. to better facilitate memory transition over T-cell exhaustion (Fig 4A).