The results of the univariate Cox regression showed that age, gender, diabetes, tumor differentiation grade, tumor T stage, tumor N stage, perineural invasion, vascular invasion, distant metastasis, anastomotic leakage, protective stoma, CA199 level, and CEA level were all associated with cancer survival in RSC patients (P < 0.05). The gene discussed is CEACAM5; the disease is diabetes mellitus.