Epsin in macrophages promoted the degradation of ABCG1 and LRP-1 through lysosomes [14,27], promoted lipid uptake, blocked cholesterol outflow and reversed cholesterol transport, and enabled macrophages to transform to the pro inflammatory direction, thereby reducing the necrotic core in atherosclerotic plaque, reducing the risk of atherosclerotic plaque rupture flowing to the brain and heart, causing stroke and coronary heart disease. Here, LRP1 is linked to Stroke.