As it is not known whether in asthma PGAP3 is expressed in ASM (a key cell in the airway in asthma regulating bronchoconstriction, airway hyperreactivity, and airway remodeling), in this study we made the novel observation that PGAP3 is significantly expressed in ASM in asthma, and that ASM derived from the lungs of asthmatics express significantly higher levels of PGAP3 compared to non-asthmatics. The gene discussed is PGAP3; the disease is asthma.