The top 5 upregulated genes after PGAP3 transfection in ASM-NA (SC) include genes previously associated to asthma, including GATA3 (log2 fold change (FC) =  4.99) [25] and ALOX5 (FC =  4.88) [26] at 48 hrs (Table 2), as well as Alcohol Dehydrogenase 1B (Class I) Beta Polypeptide (ADH1B) (log2 fold change (FC) =  1.04) [27] at 24 hrs (Table 2). The gene discussed is ADH1B; the disease is asthma.