Although the pathways that mediate PGAP3 induced ASM proliferation and contractility are not known, RNA-Sequencing of ASM expressing PGAP3 identified four genes significantly upregulated by PGAP3 that have known relevance with asthma (i.e., GATA3, ALOX5, BMP4, and SERPINB5). This evidence concerns the gene GATA3 and asthma.