The importance of PGAP3, a gene localized to chromosome 17q12-21, to the pathogenesis of asthma is suggested from genetic association studies demonstrating a link between PGAP3 SNPs and increased PGAP3 expression [1–3] as well as to asthma exacerbations [10], asthma severity [7], and asthma susceptibility [6]. This evidence concerns the gene PGAP3 and asthma.