Although the pathways that mediate PGAP3 induced ASM proliferation and contractility are not known, RNA-Sequencing of ASM expressing PGAP3 identified four genes significantly upregulated by PGAP3 that have known relevance with asthma (i.e., GATA3, ALOX5, BMP4, and SERPINB5). The gene discussed is BMP4; the disease is asthma.