Since TAMs play a critical role in supporting GBM progression (17, 18, 23, 54, 55), we evaluated whether STAT3 is critical for TAM LGMN–induced GBM growth by co-implanting CT2A cells with immunosuppressive Raw264.7 macrophages harboring shRNA control or Lgmn shRNA and treating the tumor-bearing mice with or without Colivelin (Supplemental Figure 3C). This evidence concerns the gene LGMN and neoplasm.