ITGAV and glioblastoma: Next, we used a shRNA-mediated knockdown system to deplete integrin αv (encoded by ITGAV) in SF763 and CT2A cells (Figure 4D) and found that LGMN-induced upregulation of GBM cell proliferation (Figure 4, E and F) and colony formation (Figure 4, G and H) were abolished by integrin αv depletion.