We also observed a moderate though insignificant decrease in granzyme B expression, a marker of cytotoxicity, on CD8+ T cells in the CX of BV+ versus BV– individuals (median frequency 25% BV– vs. 22% BV+, Padj = 0.094; Supplemental Table 1), with marginal differences in the VT and PBMC samples from those with versus those without BV (Figure 6B). This evidence concerns the gene CD8A and bacterial vaginosis.