The virus-inducible epigenomics signals (enriched FC; SVI6 h/0 h) derived from DNaseI-seq assays, and ChIP-seq assays against H3K27ac, H3K4me3, IRF3, NF-κB, MED1, CBP, and RNA pol II were traced/assessed to evaluate if their enhancements over the time of infection correspond to integral parts of global epigenome (re)programming settings or regional-random episodes. The gene discussed is CREBBP; the disease is infection.