We identified >1100 SHAe loci of residence in human lung A549 cells and >1400 in B-lympocytes NM that are marked by outstanding H3K27ac modification and/or IRF3-binding upon virus-infection (SVI, 6 h), and exhibit substantial specificity for defensive/antiviral and immune cellular functions (GOs). The gene discussed is IRF3; the disease is infection.