Next, QRTMs elegantly accessed the epigenetic states and functional features of viSEs assembly and validated H3K27ac, MED1, DNaseI, RNA pol II, CBP, IRF3, and p65 (co)-occupancies prior to and upon virus-infection (Fig. 4B; Supplementary Figs S15B and S16B). The gene discussed is IRF3; the disease is infection.