Upon virus-infection, additional CHs are established proximal to C/I-III members, and, frequently, are (co)-occupied by IRF3, p65, and CBP (Fig. 1C; Supplementary Fig. S9A and B, and Supplementary Table S2), consistent with the transcriptional stimulation of these vruDEGs upon virus infection. This evidence concerns the gene IRF3 and viral infectious disease.