The Disease Enrichment Analysis on this SHAe cohort highlights outstanding specificity for (auto)immune-related diseases, such as primary immunodeficiency disease, asthma, viral infectious disease etc. Most importantly dozens of the vruDEGs identified (DDX58, NFKB2, andIL7R) to associate with these diseases are also associated in cis with those 55 SHAe (Supplementary Fig. S30G, GitHub Repository), thus illuminating the commitment of these vrCRMs in cellular physiology. Here, RIGI is linked to inborn error of immunity.