Towards, this genome innovation episode, grants human cells an additional vrCRM, might facilitate the “birth” of a SE upon virus infection and might influence the fine-tuning of a human antiviral gene, thus enforcing regulatory underpinnings on this locus; (ii) SHAe can encode for new amino acids; Human CHEK2 harbors an IR-HCTFBS structured by TR and Alu elements, that is located ∼11.3 kb downstream of its TSS (Fig. 9Cii; Supplementary Fig. S27B; Supplementary Table S5), inhabits the viSE of the gene, coincides with its third exon, and exhibits substantial conservation with viral genomes. The gene discussed is CHEK2; the disease is viral infectious disease.