Contrastingly, numerous C/II and C/III members execute elevated/robust basal levels of expression and acquire an impulse of upregulation upon virus-infection (e.g. NFKBIZ), while a few establish minimal basal levels followed by slight upregulation e.g. TRIM69 (Fig. 1A and B; Supplementary Fig. S1A and Supplementary Table S1). This evidence concerns the gene TRIM69 and viral infectious disease.