YES1, a member of the Src tyrosine kinase family (SFK), is involved in multiple key cellular processes including apoptosis, cell-cell adhesion, survival, and cytoskeleton remodeling.24 Furthermore, SFK members are suggested to be involved in the signal transduction pathways in important cardiac pathophysiological processes, including myocardial ischemia-reperfusion injury, arrythmia and hypertension.25 Yet, the underlining mechanism of YES1 and its role in cardiovascular (patho-) physiology remains unraveled. Here, YES1 is linked to Hypertension.