There were also significant differences in both OS and RFS between patients with high and low ADRB2 expression, and the multivariable analysis confirmed that pT, pN, and ADRB2 expression were independent prognostic factors of poor RFS.12 In the study by Takahashi et al., higher ADRB2 expression was associated with advanced age, tumor aggressiveness, and histology of non-signet ring cells.42 Our study also revealed differences in ADRB2 expression based on histopathological subtypes. Here, ADRB2 is linked to neoplasm.