NFKB1 and gastric intestinal type adenocarcinoma: This cAMP activation is induced through PKA signaling, which also represents the main pathway of β-adrenergic receptors.11,47 The BBs might also modulate the immune response and inflammation induced by NF-kB.10,48 On the other hand, intestinal gastric adenocarcinoma has shown, in both single cell as well as bulk RNA-seq studies, lower immune scores.49,50 However, more research is currently needed to further explore these differences, and our study might contribute to more evidence in this field and the generation of hypotheses.