Basophils from patients with autoimmune pancreatitis (AIP) induced a more significant IgG4 production than those from healthy controls, indicating that TLR-mediated innate immunity represented by basophils may contribute to the development of IgG4-RD in a T-independent process that involves BAFF signals [16]. Here, TNFSF13B is linked to immunoglobulin G4-related sclerosing disease.