For example, in liver cancer, overexpression of retinoic acid-inducible gene I (RIG-I) can promote M2 polarization of peritoneal macrophages in mice through the RIG-I/MAVS/TRAF1/NF-κB pathway, thus inducing apoptosis of liver cancer cells (Zhou et al. 2020a). This evidence concerns the gene RIGI and liver cancer.