VEGFC and melanoma: The increase of M2 macrophages can promote the expression of vascular endothelial growth factor A (VEGF-A) and vascular endothelial growth factor C (VEGF-C) in non-small cell lung cancer cells, Moreover, TAM-derived adrenomedullin induces the phosphorylation of endothelial nitric oxide (NO) synthase in endothelial cells and polarizes macrophages to the M2 phenotype in an autocrine manner, promoting angiogenesis and melanoma growth (Chen et al. 2011; Hwang et al. 2020).