STAT3 and intrahepatic cholangiocarcinoma: Studies have shown that co-culture TANs with TAMs can produce higher levels of oncostatin M and IL-11, both of which activate STAT3 signaling in intrahepatic cholangiocarcinoma (ICC); Thereby enhancing the proliferation and invasion ability of ICC cells in vitro and tumor progression in the ICC mouse xenograft model (Zhou et al. 2021).