Ordinal regression analyses revealed significant association between higher salivary TNF-α and TMAO levels and higher odds to present periodontitis in an age-adjusted model (OR: 1.490; 95% CI: 1.021, 2.174; p = 0.039 for TNF-α and OR: 1.094; 95% CI: 1.003, 1.193; p = 0.044 for TMAO) (Table 4). This evidence concerns the gene TNF and periodontitis.