Furthermore, several vascular regulators reduced in SHP2-silenced mouse B16F10 cells and tumors were expressed at significantly higher levels in metastatic compared with primary human melanomas, including ANGPT1, THSB2 (codes for thrombospondin 2), PTX3, FGF7 (also known as KGF), and VEGFA (Supplemental Figure 9, F–V). This evidence concerns the gene VEGFA and melanoma.