We found that tumors generated by inoculation of SHP2-silenced MC38 (Figure 1H) and CT26 (Supplemental Figure 1L) cell lines resembled those induced by SHP2-silenced B16F10 melanoma, as they had similar growth compared with the nonsilenced (p-LKO) control tumors (Figure 1, I–K, and Supplemental Figure 1, M and N), reduced vascularization compared with controls (Figure 1, L and M, and Supplemental Figure 1, O and P), and similar vessel perfusion per unit of tumor area compared with control tumors (Figure 1N). The gene discussed is DDX53; the disease is neoplasm.