By single-cell RNA-Seq, we detected Cxcl12, Mmp3, Hgf, Serpine1, F3, Fgf2, and Cxcl16 mRNAs predominantly in B16F10 tumor–associated stromal cells expressing the genes Col1a1, Col1a2, and Sparc; to some degree, the Cxcl12, Hgf, Serpine1, and Cxcl16 genes were also expressed in CD31+ endothelial cells; additionally, Hgf and Cxcl16 genes were also expressed in CD45+ inflammatory cells (62). The gene discussed is SPARC; the disease is neoplasm.