SHP2-depleted MC38 tumors were significantly less vascularized than those derived from p-LKO control tumors (Figure 1, L and M) and structurally differed from controls in showing clusters of proliferating tumor cells surrounding normal-appearing tumor vessels separated by nonvascularized tumor composed on nonproliferating tumor cells (Supplemental Figure 8, A and B). Here, PTPN11 is linked to neoplasm.