PTPN11 and acute myeloid leukemia: Moreover, another SHP2 inhibitor, SHP099, reduced the expression of angiogenic factors in the human acute myeloid leukemia MOLM13 cells otherwise resistant to SHP2 inhibition (7) and altered the expression chemokines and cytokines in KrasG12D–driven p48-Cre; trp53lox/lox (KPC) pancreatic tumors prompting an influx of T cells (71).