FITC-dextran intensity/per unit of tumor area showed that vessels in the SHP2-depleted B16F10 tumors were perfused to a similar degree as those in the controls, which was indicative of increased vessel perfusion in the less vascularized SHP2-silenced tumors compared with p-LKO tumors (Figure 1G and Supplemental Figure 1, G and H). This evidence concerns the gene PTPN11 and neoplasm.