Thus, tumors originating from SHP2-depleted B16F10 melanoma and MC38 colon carcinoma cells displayed a distinctive signature with reduced vascularization, a restrained proinflammatory phenotype, and a subverted architecture with remarkable clustering of tumor cells around selected blood vessels, forming islands of perivascular proliferative tumor tissue separated by dead/dying tumor tissue. This evidence concerns the gene PTPN11 and melanoma.