The array also showed that the Src kinase family member p-YesY426 and, to a lesser degree, p-SrcY419, as well as the targets of p-AKT, p-PRAS40T246, and p-WNK1T60 proteins, were more active in SHP2-silenced B16F10 tumors than in control tumors, consistent with the known relative roles of these kinases in melanoma and cancer progression (20–22). This evidence concerns the gene PTPN11 and melanoma.