Imaging to detect Ki67 showed that SHP2-silenced tumors acquired a distinctive structural organization, consisting of “islands” of proliferating (Ki67+) tumor cells surrounding a central blood vessel, separated from each other by nonproliferating (Ki67–) tumor tissue mostly devoid of blood vessels (Figure 4A and Supplemental Figure 3, A and B). This evidence concerns the gene MKI67 and neoplasm.