We again found that the expression levels of several proangiogenic (n = 19), antiangiogenic (n = 3), and context-dependent (n = 2) vascular factors were reduced (>20%) in SHP2-silenced (shmL2) tumor lysates compared with controls (Figure 6D and Supplemental Figure 6H), a sizable proportion of which were the same factors reduced in SHP2-depleted (Figure 6E and Supplemental Figure 6I) and TNO155-treated (Figure 6F) B16F10 cells from in vitro culture. Here, PTPN11 is linked to neoplasm.