The viable blood vessels of SHP2-silenced B16F10 tumors differed morphologically from those in the control tumors, as the former showed reduced branching complexity (Figure 4A) accompanied by an increase in vessel caliber (Supplemental Figure 3, D and E), thus resembling tumor vessels in mice treated with agents that prune “immature” tumor vessels and “normalize” the remaining tumor vessels (24–26). The gene discussed is PTPN11; the disease is neoplasm.