PTPN11 and neoplasm: The size of tumors on day 16 (Figure 9E), when a tumor in a single mouse reached the maximum diameter, closely recapitulated the results in Figure 9, A and C. Continued treatment until the euthanasia endpoint showed that GDC-0623 was effective at extending the survival of mice bearing p-LKO tumors (P < 0.01, log-rank test) but more effective at prolonging survival of mice with SHP2-silenced (P < 0.001) B16F10 tumors (P < 0.05).