Cataracts are also a symptom of other, known phenotypes associated with COPII: SEC23A-associated craniolenticulosutural dysplasia (OMIM 607812) is characterized by cataracts, skeletal defects, and dysmorphism (23), and variants in SEC31A cause an autosomal-recessive neurodevelopmental disorder (OMIM 618651) that also includes cataracts as a prominent feature (24). The gene discussed is SEC23A; the disease is cataract.