Together with our prior findings demonstrating that CFTR modulation reduces epithelial release of the potent type 2 cytokine IL-33 and our present studies showing significant GATA3 and IL-13 reductions in human Th2 cells treated with ivacaftor compared with DMSO controls, CFTR modulation has the potential to broadly target allergic disease. This evidence concerns the gene IL33 and allergic disease.