IFNG and nonpapillary renal cell carcinoma: In both cohorts, EUR ccRCC tumors were enriched in inflammatory pathways (IFN-α and IFN-γ response, allograft rejection), proliferative pathways (E2F targets, G2–M checkpoint, Myc signaling), metabolic pathways (glycolysis, oxidative phosphorylation, fatty acid metabolism, bile acid metabolism, peroxisome, and MTORC1 signaling), and the unfolded protein response.