When comparing genetic similarity–related differences in ccRCC specimens in both JHU and TCGA datasets, we found that the EUR group was consistently enriched for pathways associated with inflammation (e.g., IFN-α and IFN-γ responses, allograft rejection), proliferation (e.g., E2F targets, G2–M checkpoint), and metabolism (e.g., glycolysis, bile acid metabolism, fatty acid metabolism, peroxisome, MTORC1 signaling). This evidence concerns the gene IFNG and nonpapillary renal cell carcinoma.