IFNB1 and infection: Through CRISPRi knockdown of VILMIR expression and RNA-seq-based transcriptome profiling in A549 cells, we found that VILMIR KD broadly dampened the host transcriptional response to both IFN-β treatment and IAV H1N1 infection, i.e., genes that were upregulated or downregulated by treatment/infection were still upregulated or downregulated, but with smaller fold changes.