KRAS and cancer: Cancer initiation is thus believed to be a rare event taking place at the level of individual cells (Visvader, 2011; Nowell, 1976; Hanahan, 2022; Pénisson et al., 2022; Frumkin et al., 2008) arising as a result of the accumulation of genetic mutations in so-called Mut-driver genes (oncogenes such as KRAS [Malumbres and Barbacid, 2003; Pylayeva-Gupta et al., 2011], tumor suppressor genes [Strachan and Read, 1999] such as TP53 or lifespan [Blasco, 2005] genes such as TERT).