STAT3 and ischemic stroke: For instance, AD16 has been shown to mitigate ischemic stroke‐induced brain injury by reducing A1 astrocyte polarization, thereby suppressing neuroinflammation via the downregulation of NF‐κB and Janus Kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) signaling pathway [39].