HMGB1 and acute myeloid leukemia: Next, to explore whether circKCNQ5 exerted its function in DNMT3A-WT AML cells through HMGB1, a rescue experiment was performed by cotransfecting si-HMGB1 and ov-circKCNQ5 into DNMT3A-WT KG-1a and HL-60 cells.