In addition, the cell proliferation and cell cycle assay results indicated that proliferation was increased; the G1-phase was reduced in DR882MUT AML cells compared to DNMT3A-WT AML cells, suggesting that DR882MUT promoted proliferation and the development of the G1-phase toward the S-phase (Figure 1B and C). This evidence concerns the gene DNMT3A and acute myeloid leukemia.