RT-qPCR analysis showed that circKCNQ5 expression was remarkably elevated in DNMT3A-WT and DR882MUT AML cells compared to mononuclear HS-5 cells, whereas circKCNQ5 expression in DR882MUT KG-1a and HL-60 cells was higher than that in DNMT3A-WT KG-1a and HL-60 cells (Figure 1D). Here, DNMT3A is linked to acute myeloid leukemia.