Remarkably, EDEM2 reinforcement rescued the deleterious effects (Figure 6B through 6G; Table S5), particularly prohibiting lipid overload (Figure 6H through 6J), oxidative stress, and cardiac hypertrophy (Figure 6K and 6L; Figure S23E) resulting from XBP1s disruption. This evidence concerns the gene EDEM2 and cardiac hypertrophy.