EDEM2 can regulate protein glycosylation and degradation18 and is involved in cellular homeostasis.19 For instance, a heterozygous EDEM2 variant causes monogenic childhood-onset diabetes, highlighting it as a diabetes-related gene.22 Although its role in protein modification will be investigated, the present observation of colocalization of EDEM2 and ERGIC53 unveils a noncanonical function of EDEM2 for protein trafficking. The gene discussed is LMAN1; the disease is diabetes mellitus.