We also demonstrated that the globo-series glycansare exclusivelyexpressed in 15 types of cancers and their stem cells20 and knockdown of β3GalT5 led to cancer cell apoptosiswith no effect on normal cells.16 Thiswork has led to the development of therapeutic cancer vaccines targetingGlobo-H and the other globo-series glycans.21 Taken together, β3GalT5 plays a pivotal role in the synthesisof TACAs and is considered as a promising target for development ofanticancer agents. This evidence concerns the gene B3GALT5 and cancer.