lncRNA MEG3, as a competing endogenous RNA (ceRNA) for miR-let-7c-5p, inhibited the interaction of miR-let-7c-5p with the binding of NLRC5’s 3' untranslated region (3'UTR), which promoted NLRC5 expression and further aggravated alcohol-induced steatosis and apoptosis (50). Here, NLRC5 is linked to alcohol dependence.