• ALT or AST >8× ULN• ALT or AST >5× ULN for >2 weeks• ALT or AST >3× ULN and total bilirubin >2× ULN or INR >1.5 (total bilirubin measurement can be within 30 days of the ALT elevation)• ALT or AST >3× ULN with the appearance of fatigue, nausea, vomiting, right upper quadrant pain or tenderness, fever, rash, and/or eosinophilia (>5%). This evidence concerns the gene GPT and Increased total eosinophil count.