2D-OIS and locomotion recordings were made across four different groups of 9- to 12-month-old mice: wild-type (N=580 locomotion events from 12 mice), Alzheimer’s disease (APP/PS1; N=761 locomotion events from 12 mice), atherosclerosis (rAAV8-mPCSK9-D377Y; N=700 locomotion events from 10 mice), and a mixed AD/atherosclerosis model (N=302 locomotion events from six mice). The gene discussed is APP; the disease is Alzheimer disease.