TMTC1 and intervertebral disk degenerative disorder: Among them, the OR values of BCKDHB, VRK1, and TMTC1 were greater than 1, the scatter plot showed that the slope of IVW was positive, and the intercept was close to 0 (Figure S2), and the forest plot showed that the overall effect of IVW was greater than 0 (Figure S3), indicating that they were risk factors for IDD.