While the OR values of TNFAIP6, CAB39L, and BID were less than 1, the scatter plot showed that the slope of IVW was negative, and the intercept was close to 0 (Figure S2), and the forest plot showed that the overall effect of IVW was less than 0 (Figure S3), indicating that they were protective factors of IDD (Figure 3A). The gene discussed is CAB39L; the disease is intervertebral disk degenerative disorder.