Concretely, FA-related candidate genes in OS and AD were primarily co-associated with “focal adhesion”, “substrate adhesion-dependent cell spreading”, “protein complex involved in cell adhesion”, “extracellular matrix structural constituent”, and “muscle cell differentiation”, etc., in GO entries (Figures 3C, D), and were mainly co-enriched in “PI3K-Akt signaling pathway”, “ECM-receptor interaction”, “human papillomavirus infection”, and “focal adhesion” and other KEGG pathways (Figures 3E, F). This evidence concerns the gene AKT1 and human papilloma virus infection.