In the GSE100930 dataset, the full gene expression was as follows: the AD group showed down-regulation of IGF1, BIRC3, and up-regulation of PAK2, LAMA4, ITGB3, ITGA8, LAMB1, ITGA4, FLNC, HGF, COL4A1, COL4A2. The gene discussed is COL4A2; the disease is Alzheimer disease.