Similarly, in AD samples, ITGB3, ITGA4, LAMB1, ITGA8 and LAMA4 showed co-enrichment in “cell cycle” and “peroxisome”, ITGB3, LAMB1, ITGA8 and LAMA4 were co-enriched in “DNA replication”, LAMB1, ITGA8 and LAMA4 were co-enriched in “spliceosome” and “valine leucine and isoleucine degradation” (Figures 5F–J). The gene discussed is ITGA4; the disease is Alzheimer disease.