Identifying 8 key genes as potential regulatory target genes for the differentiation of mesenchymal stem cells into osteoblasts or adipocytes under the condition of disuse osteoporosis (ITGB3, LAMC1, COL6A3, ITGA8, PDGFRB, ITGA4, LAMB1, LAMA4). This evidence concerns the gene LAMB1 and osteoporosis.