Identifying 8 key genes as potential regulatory target genes for the differentiation of mesenchymal stem cells into osteoblasts or adipocytes under the condition of disuse osteoporosis (ITGB3, LAMC1, COL6A3, ITGA8, PDGFRB, ITGA4, LAMB1, LAMA4). The gene discussed is ITGB3; the disease is osteoporosis.