NR3C1 and adrenal cortex carcinoma: Since tumoural NR3C1 expression has been proposed as a marker of GC excess in ACC (37), we compared protein GR expression between clinically GC-secreting and hormonally inactive tumours, but did not observe an association with clinical hormone status (Figure 6C, Supplementary Figure S2, Supplementary Table S4) suggesting that tumoural GR expression is not a marker of GC excess in ACC.