Evidence demonstrates reduced ovarian reserve function in endometriosis (7, 8): i) elevated serum concentrations of FSH and low concentrations of LH relative to FSH levels are observed in endometriosis, while lower FSH levels are potential indexes for successful postoperative pregnancy; and ii) single nucleotide polymorphisms (SNPs) in the FSH receptor (FSHR) gene and LH receptor (LHR) gene might be associated with ovulation disorders. This evidence concerns the gene PLOD1 and endometriosis.