Blood, BM, spleen, intraabdominal LN: PB: villous lymphocytes with monoclonal surface Ig with kappa light chain and mu and gamma heavy chains, CD22+, HLA-DR +, CD19+, CD20+, CD3-, CD4-, CD8-; abdominal CT scan: splenomegaly, paraaortic lymphadenopathy, and a tumor around kidneys. BM: 2% villous lymphocytes and a small nodular infiltration; splenectomy: SLVL. The gene discussed is MS4A1; the disease is neoplasm.